abstract：:Regulation of the Hypothalamus-Pituitary-Adrenal axis (HPA-axis) and its end product cortisol differs among persons with certain psychiatric disorders when compared with controls. Some reports concern Attention-Deficit/Hyperactivity Disorder (ADHD) but findings are inconclusive. In this study we collected four saliva ...

journal_title：Journal of psychiatric research

authors： Isaksson J,Nilsson KW,Nyberg F,Hogmark A,Lindblad F

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Most patients with schizophrenia suffer from various types of hallucinations, which commonly produce distress, functional disability or behavioral dyscontrol. The neural process of adapting to hallucinations in patients with schizophrenia remains unknown. METHODS:Functional magnetic resonance imaging (MRI) r...

journal_title：Journal of psychiatric research

authors： Kim JJ,Ku J,Lee H,Choi SH,Kim IY

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:We explored interaction effects involving polymorphisms of targeted dopamine system genes and selected forms of childhood abuse (sexual, physical and emotional) acting upon severity of binge-eating and psychopathological symptoms in women with Bulimia-Spectrum Disorders (BSDs). METHODS:Women diagnosed with a...

journal_title：Journal of psychiatric research

authors： Groleau P,Steiger H,Joober R,Bruce KR,Israel M,Badawi G,Zeramdini N,Sycz L

更新日期：2012-09-01 00:00:00

abstract：:The present study was aimed to investigate and compare the efficacy of duloxetine (DLX) loaded nanostructured lipid carriers (NLC) with DLX solution pharmacodynamically following intranasal administration. The study was further conducted to estimate DLX concentration in brain and blood. DLX was administered to albino ...

journal_title：Journal of psychiatric research

authors： Alam MI,Baboota S,Ahuja A,Ali M,Ali J,Sahni JK

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Investigations of gray matter changes in relation with auditory verbal hallucinations (AVH) have reported conflicting results. Assuming that alterations in gray matter might be related to certain symptoms in schizophrenia this study aimed to investigate changes in cortical thickness specific to AVH. It was...

journal_title：Journal of psychiatric research

authors： van Swam C,Federspiel A,Hubl D,Wiest R,Boesch C,Vermathen P,Kreis R,Strik W,Dierks T

更新日期：2012-08-01 00:00:00

abstract：:The impact of co-morbid substance use on mortality is not well studied in psychotic disorders. The objective of this study was to examine the impact of substance use on mortality in people with psychotic disorders and alcohol and/or drug use. We examined the rate of substance use and the risk of substance use on morta...

journal_title：Journal of psychiatric research

authors： Koola MM,McMahon RP,Wehring HJ,Liu F,Mackowick KM,Warren KR,Feldman S,Shim JC,Love RC,Kelly DL

更新日期：2012-08-01 00:00:00

abstract：:Recently, several studies have emerged suggesting a role of the intracellular survival pathways in the treatment of mood disorders. In addition, the beneficial effects of using a combination of antipsychotics and antidepressants have been shown. With this in mind, we evaluated the effects of the acute administration o...

journal_title：Journal of psychiatric research

authors： Réus GZ,Abelaira HM,Agostinho FR,Ribeiro KF,Vitto MF,Luciano TF,Souza CT,Quevedo J

更新日期：2012-08-01 00:00:00

abstract：:Previous studies with postmortem brain tissues showed abnormalities in n-3 polyunsaturated fatty acids (PUFAs) in the orbitofrontal cortex of individuals with schizophrenia and mood disorders. However, in the hippocampus, we were not able to find any significant differences in PUFAs except for small differences in n-6...

journal_title：Journal of psychiatric research

authors： Hamazaki K,Hamazaki T,Inadera H

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To examine the prevalence and correlates of comorbid anxiety disorders among individuals with bipolar disorders (BP) and their association with prospectively ascertained comorbidities, treatment, and psychosocial functioning. METHOD:As part of the National Epidemiologic Survey on Alcohol and Related Conditio...

journal_title：Journal of psychiatric research

authors： Sala R,Goldstein BI,Morcillo C,Liu SM,Castellanos M,Blanco C

更新日期：2012-07-01 00:00:00

abstract：:The etiology of side effects of antipsychotic medications can be conceptualized as involving both specific pharmacological actions of a drug and any mental and physical states attributed by the patient. Both factors are likely to be linked with neurocognitive functioning which may largely affect the subjective experie...

journal_title：Journal of psychiatric research

authors： Hwang SS,Kim Y,Yun DY,Kim YS,Jung HY

更新日期：2012-07-01 00:00:00

abstract：:Research indicates that distress tolerance exhibits a complicated relationship with risk factors for suicidal behavior. Specifically, low self-reported distress tolerance has been linked to perceived burdensomeness and thwarted belongingness. Contrastingly, high self-reported distress tolerance has been linked to the ...

journal_title：Journal of psychiatric research

authors： Anestis MD,Joiner TE

更新日期：2012-06-01 00:00:00

abstract：:Dysfunction of the N-methyl-d-aspartate receptor, which is modulated by excitatory amino acids (EAA), is involved in the pathophysiology of schizophrenia. The effects of antipsychotics on EAA metabolism are uncertain. Positive clinical effects of treatment with antipsychotics were not always associated with changes in...

journal_title：Journal of psychiatric research

authors： Hons J,Vasatova M,Cermakova E,Doubek P,Libiger J

更新日期：2012-06-01 00:00:00

abstract：:Generalized anxiety disorder (GAD) and substance use disorders (SUDs) are highly comorbid, and GAD-SUD comorbidity is associated with a host of poor psychosocial outcomes, including higher rates of hospitalization, disability, functional impairment, and inferior GAD and SUD treatment outcomes. Despite the noted severi...

journal_title：Journal of psychiatric research

authors： Magidson JF,Liu SM,Lejuez CW,Blanco C

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Various studies of child cortisol secretion and sleep show a close association between poor sleep, deterioration of the HPA axis and unfavorable psychological functioning. However, there is little evidence as to whether these associations are clearly present in pre-school children suffering from psychiatric ...

journal_title：Journal of psychiatric research

authors： Hatzinger M,Brand S,Perren S,von Wyl A,Stadelmann S,von Klitzing K,Holsboer-Trachsler E

更新日期：2012-05-01 00:00:00

abstract：:Weight gain and metabolic syndrome are the most common deleterious side effects following treatment with second generation antipsychotic drugs such as clozapine and olanzapine. However, the mechanisms underlying these negative effects of second generation antipsychotic drugs are not fully understood. In this study we ...

journal_title：Journal of psychiatric research

authors： Souza RP,Tiwari AK,Chowdhury NI,Ceddia RB,Lieberman JA,Meltzer HY,Kennedy JL,Müller DJ

更新日期：2012-04-01 00:00:00

abstract：:The goal of this article is to highlight the significant potential benefits of applying computational mathematical models to the field of psychiatry, specifically in relation to diagnostic conceptualization. The purpose of these models is to augment the current diagnostic categories that utilize a "snapshot" approach ...

journal_title：Journal of psychiatric research

authors： Bystritsky A,Nierenberg AA,Feusner JD,Rabinovich M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Structural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executive cognitive function and episodic memory. Impairment in these cognitive functions is associated with increased vulnerability...

journal_title：Journal of psychiatric research

authors： Soloff PH,Pruitt P,Sharma M,Radwan J,White R,Diwadkar VA

更新日期：2012-04-01 00:00:00

abstract：:A self-report version of the Lifetime History of Impulsive Behaviors (LHIB) interview was developed and its psychometric properties examined. Initially, forty-two personality disordered and 20 control subjects completed both the interview (I) and self-report (Q53) versions of the LHIB along with other self-report meas...

journal_title：Journal of psychiatric research

authors： Coccaro EF,Schmidt-Kaplan CA

更新日期：2012-03-01 00:00:00

abstract：:Recent evidence suggests that children with autism have impaired detoxification capacity and may suffer from chronic oxidative stress. To our knowledge, there has been no study focusing on oxidative metabolism specifically in Asperger syndrome (a milder form of autism) or comparing this metabolism with other psychiatr...

journal_title：Journal of psychiatric research

authors： Parellada M,Moreno C,Mac-Dowell K,Leza JC,Giraldez M,Bailón C,Castro C,Miranda-Azpiazu P,Fraguas D,Arango C

更新日期：2012-03-01 00:00:00

abstract：:Recent reports of increasing suicide rates among military personnel indicate a need for increased work in understanding processes relevant to suicide risk in the military. Anxiety, along with anxiety-related risk factors have been implicated in suicidality as well as posttraumatic stress disorder (PTSD). One such risk...

journal_title：Journal of psychiatric research

authors： Capron DW,Cougle JR,Ribeiro JD,Joiner TE,Schmidt NB

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM:To assess serum GDNF concentration in elderly subjects with late-life depression, befo...

journal_title：Journal of psychiatric research

authors： Diniz BS,Teixeira AL,Miranda AS,Talib LL,Gattaz WF,Forlenza OV

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To examine gender differences in the associations of levels of pain interference and psychiatric disorders among a nationally representative sample of adult men and women. METHOD:Chi-square tests and multinomial logistic regression analyses were performed on data obtained from the National Epidemiologic Surv...

journal_title：Journal of psychiatric research

authors： Barry DT,Pilver C,Potenza MN,Desai RA

更新日期：2012-01-01 00:00:00

abstract：:Social anxiety disorder (SAD) is highly prevalent and impairing. Little is known about rates and predictors of persistence of SAD in the community. The current study derived data from the National Epidemiologic Survey on Alcohol and Related Conditions, Wave 1 (2001-2002, n = 43,093) and Wave 2 (2004-2005, n = 34,653),...

journal_title：Journal of psychiatric research

authors： Blanco C,Xu Y,Schneier FR,Okuda M,Liu SM,Heimberg RG

更新日期：2011-12-01 00:00:00

abstract：:People with a psychiatric illness are at high risk for suicide; however, variation of the risk by patients' sex and age and by specific diagnosis needs to be explored in a more detail. This large population study systematically assesses suicide incidence rate ratio (IRR) and population attributable risk (PAR) associat...

journal_title：Journal of psychiatric research

authors： Qin P

更新日期：2011-11-01 00:00:00

abstract：:The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 11...

journal_title：Journal of psychiatric research

authors： Nohesara S,Ghadirivasfi M,Mostafavi S,Eskandari MR,Ahmadkhaniha H,Thiagalingam S,Abdolmaleky HM

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To examine the longitudinal course of pediatric bipolar (BP)-I disorder in youth transitioning from childhood into adolescence. METHODS:We conducted a four year prospective follow-up study of 78 youth with BP-I disorder 6-17 years old at ascertainment followed up into adolescent years (13.4 ± 3.9 years). All...

journal_title：Journal of psychiatric research

authors： Wozniak J,Petty CR,Schreck M,Moses A,Faraone SV,Biederman J

更新日期：2011-10-01 00:00:00

abstract：RESEARCH QUESTIONS:Wearing a protective mask is compulsory for those in professions such as fire-fighters, rescue personnel and soldiers. The phobia to wear a protective mask is considered a specific claustrophobia and may become of major concern during military service. To date, no data are available with respect to t...

journal_title：Journal of psychiatric research

authors： Brand S,Annen H,Holsboer-Trachsler E,Blaser A

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:Both decrease in bone mineral density and increase in bone turnover had been reported in patients with major depression compared to healthy controls. But the effect of antidepressant treatment on markers of bone turnover is not studied. The aim of this study was to investigate the effect of treatment of a ma...

journal_title：Journal of psychiatric research

authors： Aydin H,Mutlu N,Akbas NB

更新日期：2011-10-01 00:00:00

abstract：:Although sleep disturbance has been shown to be associated with psychological distress and the hypothalamic-pituitary-adrenal (HPA) axis function, the simultaneous relationship between sleep, distress and HPA axis function is less clear. Here we examined the relationship between sleep quality as assessed with the Pitt...

journal_title：Journal of psychiatric research

authors： Hori H,Teraishi T,Sasayama D,Ozeki Y,Matsuo J,Kawamoto Y,Kinoshita Y,Hattori K,Higuchi T,Kunugi H

更新日期：2011-09-01 00:00:00

abstract：:A dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis represents a prominent finding in major depression, possibly related to a dysfunction of the corticosteroid receptor system. Antidepressants are involved in the restoration of the altered feed-back mechanism of the HPA-axis, probably via normaliza...

journal_title：Journal of psychiatric research

authors： Enning F,Murck H,Krieg JC,Vedder H

更新日期：2011-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays a central role in synaptic plasticity and neurogenesis. Bipolar disorder (BD) is among the most disabling of all psychiatric disorders and is associated with poor outcomes. Some studies suggest that BDNF levels decrease during mood states and remain normal during euthymia...

journal_title：Journal of psychiatric research

authors： Fernandes BS,Gama CS,Ceresér KM,Yatham LN,Fries GR,Colpo G,de Lucena D,Kunz M,Gomes FA,Kapczinski F

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Treatment-resistant major depressive disorder (MDD) is a complex condition, with very low remission rates. Physical exercise has been used, with some encouraging results, as an alternative therapy in other depressive disorders. This study assessed the impact on depression and functioning parameters of a mode...

journal_title：Journal of psychiatric research

authors： Mota-Pereira J,Silverio J,Carvalho S,Ribeiro JC,Fonte D,Ramos J

更新日期：2011-08-01 00:00:00

abstract：:Discussion surrounds the question as to whether criteria for generalized anxiety disorder (GAD) should change, particularly in youth. This study examines the effects of possible criteria changes on GAD prevalence and clinical correlates. DSM-IV GAD was assessed using the M-CIDI in a community sample of adolescents and...

journal_title：Journal of psychiatric research

authors： Beesdo-Baum K,Winkel S,Pine DS,Hoyer J,Höfler M,Lieb R,Wittchen HU

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Although, a large population-based literature exists on the relationship between childhood adversity and Axis I mental disorders, research on the link between childhood adversity and Axis II personality disorders (PDs) relies mainly on clinical samples. The purpose of the current study was to examine the rel...

journal_title：Journal of psychiatric research

authors： Afifi TO,Mather A,Boman J,Fleisher W,Enns MW,Macmillan H,Sareen J

更新日期：2011-06-01 00:00:00

abstract：:The specificity of relationships between anxiety and depressive symptoms, with each of the major atopic disorders of asthma, allergic rhinitis (AR), and atopic dermatitis (AD) was systematically investigated within a single study sample. Participants included 367 adolescents who participated in a community, longitudin...

journal_title：Journal of psychiatric research

authors： Slattery MJ,Essex MJ

更新日期：2011-06-01 00:00:00

abstract：:Pilot studies represent a fundamental phase of the research process. The purpose of conducting a pilot study is to examine the feasibility of an approach that is intended to be used in a larger scale study. The roles and limitations of pilot studies are described here using a clinical trial as an example. A pilot stud...

journal_title：Journal of psychiatric research

authors： Leon AC,Davis LL,Kraemer HC

更新日期：2011-05-01 00:00:00

abstract：:Major depressive disorder (MDD) is characterized by the presence of disturbances in emotional processing. However, the neural correlates of these alterations, and how they may be affected by therapeutic interventions, remain unclear. The present study addressed these issues in a preliminary investigation using functio...

journal_title：Journal of psychiatric research

authors： Ritchey M,Dolcos F,Eddington KM,Strauman TJ,Cabeza R

更新日期：2011-05-01 00:00:00

abstract：:Cannabis use is associated with onset of psychosis in individuals vulnerable for developing schizophrenia-spectrum disorders. The present study addressed three knowledge gaps pertaining to this issue: 1) clarifying the incidence of cannabis use in schizotypal individuals, 2) examining how cannabis use is related to ps...

journal_title：Journal of psychiatric research

authors： Cohen AS,Buckner JD,Najolia GM,Stewart DW

更新日期：2011-04-01 00:00:00

abstract：:More than 50 years ago, Fish postulated that a special form of early abnormal neurodevelopment, "pandysmaturation", defined a priori as constituting retarded cranial development in the first year of life, combined with delay in early motor milestone attainment, was related to genetic risk for schizophrenia, and was as...

journal_title：Journal of psychiatric research

authors： McNeil TF,Fish B,Schubert EW

更新日期：2011-04-01 00:00:00

abstract：:Persons with schizophrenia often appraise other individuals as threatening or persecutory. To evaluate social appraisal in schizophrenia, we probed brain networks with a task in which subjects judged whether or not they liked face stimuli with emotional expressions. We predicted that appraising negative expressions wo...

journal_title：Journal of psychiatric research

authors： Taylor SF,Chen AC,Tso IF,Liberzon I,Welsh RC

更新日期：2011-04-01 00:00:00